Mono and Inyo counties are located in the eastern part of California, along the border with Nevada. They are home to some of the most scenic and diverse landscapes in the state, such as the Sierra Nevada mountains, Yosemite National Park, Death Valley National Park, Mono Lake, and Mammoth Lakes.

The main road that connects these counties is U.S. Route 395, which runs north-south parallel to the Sierra Nevada range. It is designated as a scenic highway by the California Department of Transportation from Fort Independence to Fort Springs Road in Inyo County, and from the Inyo–Mono county line to south of Walker³. Along this route, you can access many attractions and recreation areas, such as Mount Whitney, Manzanar National Historic Site, Bishop, Lee Vining, June Lake Loop, Mammoth Lakes, Mono Lake, Bodie State Historic Park, Bridgeport, and Walker.