US 421 traverses Indiana, connecting major highways like I-65 and I-74. It passes through the cities of Madison, North Vernon, and Greensburg.
US 421: 1-094-034-6-1-rwis @ US 421 (MICHIGAN CITY)
US 421: 01-006-011-cam1 US421 @ 116th/Sycamore
US 421: 2-421-052-0-1-rwis GREENSBURG
OLD US 421: 11-049-186-cam RAYMOND ST & SOUTHEASTERN AVE
